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Sulfates are the foremost circulating conjugates of ethinyl estradiol and glucuronides predominate in urine. The first oxidative metabolite is 2-hydroxy ethinyl estradiol, formed because of the CYP3A4 isoform of cytochrome P450. Part of the main-go metabolism of ethinyl estradiol is thought to occur in gastrointestinal mucosa. Ethinyl estradiol may